Huberman Lab discusses neuroscience: how our brain and its connections with the organs of our body control our perceptions, our behaviors, and our health. We also discuss existing and emerging tools for measuring and changing how our nervous system works. Dr. Andrew Huberman is a tenured Professor of Neurobiology and Ophthalmology at Stanford School of Medicine. His laboratory studies neural regeneration, neuroplasticity, and brain states such as stress, focus, fear, and optimal performance. For

In this episode my guest is Nolan Williams M.D. a triple board-certified psychiatrist neurologist and professor of psychiatry and behavioral sciences at Stanford School of Medicine. He is also the Director of the Stanford Brain Stimulation Lab. We discuss clinical applications for brain stimulation behavioral protocols and novel drug treatments to halt and reverse mental health disorders including depression and post-traumatic stress disorder (PTSD). We first discuss the neural circuits for self-identity and mood and stress control. We discuss Dr. Williams’ work using transcranial magnetic stimulation (TMS) to depression trauma PTSD and other mood disorders. We then dive deep into the history biology modern use and safety margins of the various psychedelics including MDMA LSD ketamine ibogaine ayahuasca and psilocybin as well as cannabis and the use of SSRIs in both adults and children. Finally we discuss behavioral treatments for mental health disorders including sleep and sleep deprivation light exposure exercise and training to control the brain-heart-rate pathways. Regardless of age all those interested in mental health should benefit from the incredible breadth and depth of Dr. Williams’ knowledge and the clarity with which he conveys that information. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman InsideTracker: https://insidetracker.com/huberman Maui Nui: https://mauinuivenison.com/huberman Thesis: https://takethesis.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman Huberman Lab Premium https://hubermanlab.com/premium For the full show notes visit hubermanlab.com Timestamps (00:00:00) Dr. Nolan Williams Brain Stimulation & Depression Treatment (00:03:31) Huberman Lab Premium (00:04:42) InsideTracker Eight Sleep ROKA (00:08:37) Momentous Supplements (00:09:16) Depression Risk Factors Emergency Psychiatric Treatments (00:15:11) The Brain-Heart Connection Vagus Nerve Prefrontal Cortex (00:17:51) Right vs. Left Brain Hemispheres & Mood Balance Connectome (00:22:34) Heart Rate & Depression Behavioral Interventions Transcranial Magnetic Stimulation (TMS) (00:33:02) Prefrontal Cortex & Cognitive Control TMS (00:37:46) AG1 (Athletic Greens) (00:39:00) Belief/Identity “Rules” Re-scripting TMS & Talk Therapy (00:45:49) Dorsolateral Prefrontal Cortex TMS & Depression Treatment (00:48:36) Cingulate Cortex & Emotion Dissociation & Catatonia (00:54:27) Ketamine the Opioid System & Depression; Psychedelic Experience or Biology? (01:03:42) SSRIs Serotonin & Depression; Childhood Chemical Imbalance or Circuit? (01:13:58) Memories & “Rule” Creation; Psilocybin & “Rule” Resolution (01:21:00) MDMA & Post-Traumatic Stress Disorder (PTSD) Treatment Psilocybin & Depression Treatment (01:24:12) Is MDMA Neurotoxic? Drug Purity Dopamine Surges Post-MDMA Prolactin (01:30:38) Psilocybin Brain Connectivity & Depression Treatment (01:34:53) Exposure Response Prevention: “Letting Go” & Depression Treatment (01:41:23) Normal Spectrums for Mental Health Disorders (01:45:35) Ibogaine & “Life Review”; PTSD Depression & Clinical Trials (01:57:16) Clinical Use of Psychedelics (02:01:59) Ayahuasca Brazilian Prisoner Study (02:06:55) Cannabis: THC CBD & Psychosis Clinical Uses (02:14:52) Personal Relative Drug Risk & Alcohol (02:20:42) Circadian Reset for Depression Sleep Deprivation Light (02:28:43) Stanford Neuromodulation Therapy (SNT) Study (02:34:25) Space Learning Theory & TMS Stimulation (02:45:35) Zero-Cost Support YouTube Feedback Spotify & Apple Reviews Sponsors Huberman Lab Premium Neural Network Newsletter Social Media Title Card Photo Credit: Mike Blabac Disclaimer

Dr. Nolan Williams: Psychedelics & Neurostimulation for Brain Rewiring | Episode 93

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