Huberman Lab discusses neuroscience: how our brain and its connections with the organs of our body control our perceptions, our behaviors, and our health. We also discuss existing and emerging tools for measuring and changing how our nervous system works. Dr. Andrew Huberman is a tenured Professor of Neurobiology and Ophthalmology at Stanford School of Medicine. His laboratory studies neural regeneration, neuroplasticity, and brain states such as stress, focus, fear, and optimal performance. For

In this episode I explain the biology symptoms causes and types of bipolar disorder (sometimes called bipolar depression). I discuss neuroplasticity and how the brain normally regulates mood energy and perceptions; then I contrast that with the biology of bipolar disorder which is characterized by extremes of energy and mood e.g. mania and depression. I outline the mechanisms through which bipolar disorder manifests in the brain including deficits of interoception and reduced connections between the parietal and limbic systems. I also outline how treatment options (such as lithium) work in part through homeostatic plasticity.’ I discuss not only lithium but also the treatment of bipolar with ketamine different talk therapies electroconvulsive therapy transcranial magnetic stimulation and nutraceuticals including Omega-3 and Inositol supplementation. This episode should interest anyone who has or knows someone with bipolar disorder and more broadly those interested in how the brain works to create a balance between thoughts energy levels focus and mood. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman InsideTracker: https://insidetracker.com/huberman Maui Nui: https://mauinuivenison.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman For the full show notes visit hubermanlab.com Timestamps (00:00:00) Bipolar Disorder (00:02:23) Momentous Supplements (00:03:42) Tool: Appetite Suppression & GLP-1 Parallel Pathways Yerba Mate (00:10:23) AG1 (Athletic Greens) InsideTracker Thesis (00:14:24) Prevalence & Severity of Bipolar Disorder (00:16:30) Bipolar Disorder I Diagnostic Criteria of Mania (00:28:58) Bipolar Disorder II Individual Variability (00:33:07) Bipolar I vs. Bipolar II: Manic Depressive & Symptom-Free States (00:38:20) Consequences of Bipolar Disorder Heritability (00:46:53) Bipolar Disorder vs. Borderline Personality Disorder (00:51:51) Mania & Depression Negative Impacts (00:53:06) History of Lithium Treatment (01:02:44) Lithium Treatment & Side-Effects (01:05:05) Effects of Lithium: BDNF Anti-inflammatory & Neuroprotection (01:10:10) Neural Circuits of Bipolar Disorder Interoception Hyper- vs. Hypoactivity (01:17:11) Neural States & Mania Parietal Lobe & Limbic System (01:22:58) Homeostatic Plasticity Synaptic Scaling Lithium & Ketamine (01:36:00) Talk Therapies: Cognitive Behavioral Therapy Family-Focused Therapy Interpersonal & Social Rhythm Therapy (01:43:18) Electroconvulsive Therapy (ECT) Transcranial Magnetic Stimulation (rTMS) (01:48:01) Psylocibin Cannabis (01:51:50) Lifestyle Support Supplements: Inositol & Omega-3 Fatty Acids (02:03:31) Omega-3s Membrane Fluidity & Neuroplasticity (02:06:44) Mania Creativity & Occupations (02:15:33) Bipolar Disorder: Diagnosis Neural Circuits & Treatment (02:17:45) Zero-Cost Support YouTube Feedback Spotify & Apple Reviews Sponsors Momentous Supplements Instagram Twitter Neural Network Newsletter Title Card Photo Credit: Mike Blabac Disclaimer

The Science & Treatment of Bipolar Disorder | Episode 82

Huberman Lab